Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic acid ReagentPlus(R), 99% | 76-05-1 | MFCD00004169 | 2L
Trifluoroacetic acid ReagentPlus(R), 99% | Purity: 99% | Mol Wt: 114.02 | 76-05-1 | MFCD00004169 | 2L
Medchemexpress LLC Siivfekl (Tfa) | 99.85% | 948.16 | 1 MG
SIIVFEKL TFA is an antigenic peptide, a variant of the major MHC class I-restricted epitope SIINFEKL. It is designed to stimulate specific T cells in experimental settings to study the competitive interaction between T cells. This peptide exhibits low affinity for the OT-I T cell receptor (TCR) and is suitable for the detection of CD8+ T cells.
- Variant of the major MHC class I-restricted epitope SIINFEKL
- Stimulates specific T cells for competitive interaction studies
- Exhibits low affinity for the OT-I T cell receptor (TCR)
- Suitable for detection of CD8+ T cells
- High purity of 99.85%
- Provided as a white to off-white solid
- Stable under recommended storage conditions
eMolecules 76-05-1 | Trifluoroacetic acid | Chem-Impex | MFCD00004169 | 114.023 | C2HF3O2 | 99.000 | OC(=O)C(F)(F)F | 1kg | 272384819
Trifluoroacetic acid | Chem-Impex | 76-05-1 | MFCD00004169 | 114.023 | C2HF3O2 | 99.000 | OC(=O)C(F)(F)F | 1kg | 272384819
Medchemexpress LLC Ss47 Tfa | 00-00-0 | 99.9% | 1067.09 | C51H57F3N6O14S | 5 MG
SS47 TFA is a PROTAC-based HPK1 degrader supplied as the trifluoroacetic acid salt for research use. It promotes proteasome-mediated degradation of HPK1 and is used in immuno-oncology and CAR-T cell studies.
- Research reagent for HPK1 degradation and immuno-oncology studies.
- Contains an alkyne moiety compatible with copper-catalyzed azide-alkyne cycloaddition.
- Purity 99.88%.
- Chemical formula C51H57F3N6O14S; molecular weight 1067.09.
- Soluble in DMSO at 100 mg/mL; ultrasonic assistance recommended.
- Store protected from light under nitrogen; in solvent: -80°C (6 months), -20°C (1 month).
- Available in small research pack sizes such as 1 mg, 5 mg, and 10 mg.
Medchemexpress LLC AH-D peptide TFA | 98.8% | 3283.75 | 5 MG
AH-D peptide TFA is an antiviral peptide that selectively disrupts membrane structures within the size range of exosomes, inducing T-EXO depletion and enhancing cancer immunotherapy.
- Antiviral peptide
- Disrupts membrane structures within exosome size range
- Induces T-EXO depletion
- Enhances cancer immunotherapy
- Solid, white to off-white appearance
- Store sealed, away from moisture
- Powder storage at -80°C for 2 years, -20°C for 1 year
- In solvent storage at -80°C for 6 months, -20°C for 1 month
Medchemexpress LLC Astressin 2B TFA | 98.5% | 4041.69 | 1 MG
Astressin 2B TFA is a blood-brain barrier-impermeable, highly selective CRFR2 antagonist. It blocks protective effects mediated by CRFR2, exacerbating indomethacin-induced hemorrhagic intestinal injury in rats. This compound reverses the protective effects of Urocortin 1 against intestinal hypermotility, bacterial invasion, and upregulation of inflammatory mediators. It is an important tool molecule for investigating intestinal protective mechanisms of CRFR2.
- Highly selective CRFR2 antagonist
- Blocks anxiogenic effect of Urocortin 2
- Attenuates stress-induced anxiety-related behaviors
- Exacerbates intestinal epithelial damage in specific models
- Important tool for investigating intestinal protective mechanisms of CRFR2
Medchemexpress LLC K1 peptide TFA | 98.2% | 1489.59 (free acid) | 1 MG
K1 peptide TFA is a high-affinity peptide ligand for GABAA receptor-associated protein (GABARAP).
- High-affinity peptide ligand for GABAA receptor-associated protein (GABARAP)
- Solid appearance
- White to off-white color
- Target: GABA Receptor
- Pathway: Membrane Transporter/Ion Channel, Neuronal Signaling
- Powder storage: -80°C for 2 years, -20°C for 1 year
- In solvent storage: -80°C for 6 months, -20°C for 1 month
Medchemexpress LLC Iberiotoxin (TFA) | 4230.85 | 500 UG
Iberiotoxin (TFA) is a selective high conductance Ca2+-activated K+ channel inhibitor with a Kd of approximately 1 nM. It does not block other types of voltage-dependent ion channels.
- Selective high conductance Ca2+-activated K+ channel inhibitor
- Kd of approximately 1 nM
- Does not block other types of voltage-dependent ion channels
Medchemexpress LLC FLAG peptide TFA | 99.6% | 1012.97 | 5 MG
FLAG peptide TFA is the trifluoroacetic acid salt form of FLAG peptide, often denoted as HY-P0223. It functions as a versatile fusion tag specifically designed for the purification of recombinant proteins. This peptide plays a crucial role in maintaining the natural, functional folding of the proteins it is fused with, ensuring their biological activity. It can be efficiently removed by enterokinase and is capable of being eluted under non-denaturing conditions, which is beneficial for preserving protein integrity.
- Multifunctional fusion tag
- Used for purification of recombinant proteins
- Maintains natural folding of fusing proteins
- Can be removed by enterokinase
- Eluted under non-denaturing conditions
Medchemexpress LLC NH2-UAMC1110 TFA | 2990021-73-1 | C23H24F5N5O5 | 5 MG
NH2-UAMC1110 TFA | 2990021-73-1 | C23H24F5N5O5 | 5 MG
Medchemexpress LLC dTAGV-1 TFA | 2624313-15-9 | 99.9% | C70H91F3N6O16S | 1 MG
dTAGV-1 TFA is a potent and selective PROTAC degrader targeting FKBP12F36V-tagged proteins. It is capable of inducing degradation of FKBP12F36V-Nluc both in vitro in 293FT cells and in vivo in animal models.
- Potent and selective degrader of FKBP12F36V-tagged proteins.
- Induces degradation of FKBP12F36V-Nluc in vivo.
- Effective in 293FT cells.
- Reduces bioluminescent signal in animal models.