Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
SIGMA ALDRICH FINE CHEMICALS BIOSCIENCES LC-MS TRIFLUOROACETIC ACID50ML
NC2952351 LC-MS TRIFLUOROACETIC ACID50ML
Medchemexpress LLC SETD2-IN-1 (TFA) | 2411759-92-5 | 97.2% | 514.51 | 100 MG
EZM0414 TFA is the TFA salt form of EZM0414. It is a potent, selective, and orally active inhibitor of SETD2, with an IC50 of 18 nM in a biochemical assay and 34 nM in a cellular assay. This product is intended for research related to relapsed or refractory multiple myeloma and diffuse large B-cell lymphoma.
- Potent, selective, and orally active inhibitor of SETD2.
- Inhibits proliferation of multiple myeloma and diffuse large B-cell lymphoma cell lines.
- Demonstrated robust tumor growth regressions in xenograft models.
- Correlated with reductions in intratumoral H3K36me3 levels.
- Well-tolerated in animal models.
- Exhibits high oral bioavailability in rats and mice.
Medchemexpress LLC Homoglutathione trifluoroacetate | 435.37 | C13H20F3N3O8S | 25mg
Homoglutathione (TFA) is a biological molecule
Medchemexpress LLC Relamorelin (TFA) | 2863659-22-5 | 99.8% | 905.00 | 25 MG
Relamorelin TFA is a pentapeptide ghrelin analog and a selective ghrelin/growth hormone secretagogue receptor (GHSR) agonist with a Ki of 0.42 nM for the GHS-1a receptor. It is centrally penetrant, increases growth hormone levels, and accelerates gastric emptying. This compound has potential for research into cachexia, gastroparesis, and gastric/intestinal dysmobility disorders.
- Pentapeptide ghrelin analog
- Selective ghrelin/growth hormone secretagogue receptor (GHSR) agonist
- Ki of 0.42 nM for GHS-1a receptor
- Centrally penetrant
- Increases growth hormone levels
- Accelerates gastric emptying
- Shows ~3 times greater affinity for GHS-1a (Ki=0.42 nM) than native ghrelin (Ki=1.12 nM)
- 6 times more potent (EC50=0.71 nM) in activating the GHS-1a receptor than native ghrelin (EC50=4.2 nM) in vitro by calcium mobilization
- Solid appearance, white to off-white color
- For research use only.
Apexbio Technology LLC BIBP 3226 trifluoroacetate(Synonyms: BIBP3226 TFA, BIBP3226 trifluoroacetate salt, NPY Y1 receptor antagonist BIBP3226), 2mg, CAS: 1068148-47-9.
BIBP 3226 trifluoroacetate (CAS 1068148-47-9) is a non-peptide antagonist targeting neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptors showing binding affinity with Ki values of 1 1 nM (rNPY Y1) 79 nM (hNPFF2) and 108 nM (rNPFF) BIBP 3226 competes with NPFF prevents NPFF-induced inhibition of forskolin-stimulated cAMP production and blocks NPFF-dependent hypothermic and anti-opioid effects in rodent models This compound is employed experimentally to investigate NPY/NPFF system roles in anxiety analgesia and cardiovascular regulation
Medchemexpress LLC Ile-AMS TFA | 219931-45-0 | MFCD31619268 | 98.6% | 572.52 g/mol | C18H27F3N8O8S | 10 MG
Ile-AMS TFA is the trifluoroacetic acid (TFA) salt of an aminoacyl-sulfamoyl adenosine analogue that inhibits isoleucyl-tRNA synthetase and displays potent antiparasitic activity (P. falciparum ABS IC50 = 1.19 nM). Intended for laboratory research use only.
- Purity 98.55%.
- Molecular weight 572.52 g/mol; chemical formula C18H27F3N8O8S.
- Soluble in water (≈100 mg/mL); ultrasonic assistance may be required.
- Recommended storage: sealed, away from moisture; in solvent -80°C (6 months) or -20°C (1 month).
- Available in small research quantities, including a 10 mg package.
- Used as a tool compound for studies of aminoacyl-tRNA synthetase inhibition and antiparasitic research.
Medchemexpress LLC 2H-Cho-Arg (TFA) | 1609010-59-4 | 99% | 886.06 | 1 MG
2H-Cho-Arg (TFA) is a steroid-based cationic lipid that contains a 2H-cholesterol skeleton coupled to an L-arginine head group and can be used to facilitate gene transfection.
- Steroid-based cationic lipid
- Contains a 2H-cholesterol skeleton
- Coupled to an L-arginine head group
- Facilitates gene transfection
- Stable under recommended storage conditions
- For research use only
Medchemexpress LLC Ecallantide TFA | 9007-83-4 | 99.54% | 7053.81 | 50 MG
Ecallantide TFA is a specific recombinant plasma kallikrein inhibitor that works by inhibiting the production of bradykinin, thereby offering a potential treatment for acute attacks of angioedema.
- Specific recombinant plasma kallikrein inhibitor
- Inhibits the production of bradykinin
- May be used to prevent acute attacks of angioedema
Medchemexpress LLC Achn-975 Tfa | 1410809-37-8 | 99.0% | 483.44 | 25 MG
ACHN-975 TFA is a selective LpxC inhibitor that demonstrates subnanomolar LpxC inhibitory activity. It is effective against a broad spectrum of gram-negative bacteria, exhibiting low MIC values (≤1 μg/mL).
- Selective LpxC inhibitor
- Exhibits subnanomolar LpxC inhibitory activity
- Effective against a wide range of gram-negative bacteria with low MIC values (≤1 μg/mL)
- Potent against *P. aeruginosa* isolates
- Demonstrates bactericidal activity against *P. aeruginosa* ATCC27853 strain in vivo.
Medchemexpress LLC CGGRGD TFA | 98.7% | 677.61 | 5 MG
CGGRGD TFA is a derivative of RGD (Arginine-Glycine-Aspartic acid) that includes cysteine at its N-terminal. This product is intended for research applications only and not for human use. It is referenced in publications regarding the functionalization of PCL fibrous membranes with RGD peptide.
- Biological activity: a derivative of RGD with cysteine at its N-terminal
- Purity: 98.66%
- Molecular weight: 677.61
- Formula: C21H34F3N9O11S
- Appearance: solid
- Color: white to off-white
- Sequence: Cys-Gly-Gly-Arg-Gly-Asp
- Sequence shortening: CGGRGD
- Solubility in vitro: soluble in DMSO at 100 mg/mL (147.58 mM); ultrasonic assistance may be needed, and newly opened DMSO is recommended due to hygroscopic impact on solubility